Products under Advanced Development:

Orion Integrated Biosciences Inc. is currently testing two independent but interoperable pathogen detection products combining advances on nanofabrication (BARNANO) and microarray (IMVIS). Our detection platforms are enhanced by a new generation of analysis and visualization algorithms. We have the capability to extensively test and validate these devices in less than 18 months and become compliant with FDA diagnostics standards.

A. IMVIS: Integrated Microarray Viral Interrogation System

Microarray technology has been proven to be a powerful tool with great potential in pathogen diagnostics. Through miniaturization and multiplexing we can construct a comprehensive microarray viral diagnostics system capable to detect the presence of both know and unknown viral species and strains. While several researchers are using microarrays for diagnostics, our approach is different. First, we avoid completely the use of long probes (70mer) and PCR products (amplicons). Second, the length of each genomic signature probes used in our arrays significantly reduces the fabrication cost. Third, each oligo-probe is ultrapecific to a large number of known and unknown strain and we can provide a device with greater specificity and sensitivity. A single nucleotide mismatch is enough to destabilize the hybridization. This approach generates patterns that are integrated in our computational analysis system (Figure 1) and can quickly identify viral specie or strain independent partial or complete genome amplification.

B. Integrated Computational Analysis System (ICAS)

ICAS is a high performance computational architecture allows a large number of users to store, retrieve and exchange molecular and diagnostic and data concerning viral pathogens. ICAS is designed provides the tools for query optimization and it automatically updated and capable to interoperate with external databases. ICAS uses hybridization signals generated by random amplification of nucleic acids from samples suspected of been infected with any DNA and RNA viruses and match this information to a pathogen genomic catalog. Powerful computational algorithms and visualization tools will quickly determine if a virus is natural, engineered, endemic or imported. Because we have analyzed all sequence publicly available for these pathogens and collected temporal and geographical distribution information, clinical, pathological conditions. There several components that allow ICAS to quickly estimate the risk factor and outbreak potential of each detected pathogen. The ICAS can speed up the decision making process of U.S. government and researchers and deter, defend and prevent the use of biological warfare agents. ICAS can greatly facilitate the logistics of mobilizing supplies to areas of exposure or during a disease outbreak.